現在情報収集中ですが1997年11月16日までに得られた情報を掲載します

商品名	メーカー	主な成分
キシリデント	ライオン	キシリトール9％ フッ化ナトリウム950ppm
DENT Check-Up	ライオン	歯科医院専用として発売されているが、キシリデントと中身は同じとメーカーは説明している。
クール＆クリーン （液体歯磨き）	ロッテ	キシリトール25％ 塩化セチルピリジニウム・グリチルリチン酸ジカリウム・イソプロピルメチルフェノール

• フッ素を1000ppm前後含む歯磨き粉は他にも多数市販されており、これらの商品に特有の成分ではありません。
• キシリトールそのものには抗齲蝕性が認められますが、歯磨き粉に配合した場合にどれほどの虫歯予防効果が得られるかは疑問が残ります。（海外での文献より判断して）

• キシリトール入りの歯磨き粉を用いたからといって、虫歯を完全に予防できるわけではありません。
• 当然ながら普段の食生活や歯磨きにも注意が注意が必要です。

Petersson LG Birkhed D Gleerup A Johansson M Jonsson G

Caries-preventive effect of dentifrices containing various types and　concentrations of fluorides and sugar alcohols.

In: Caries Res (1991) 25(1):74-9

The caries-inhibiting effect of unsupervised daily use of four　different toothpastes was compared in a 3-year clinical and　microbiological study: (1) 0.8% sodium monofluorophosphate (MFP) with　3% xylitol and 6% sorbitol; (2) 0.03% sodium fluoride with 3% xylitol　and 6% sorbitol; (3) 0.8% MFP with 9% sorbitol, and (4) 0.03% sodium　fluoride with 9% sorbitol. In all 284 children, 12-13 years old at　 baseline, took part in the study. After 3 years, no statistically　significant differences were found between the different toothpaste groups concerning either development of initial or gross caries　lesions or number of mutans streptococci and lactobacilli in saliva. However, children with no detectable approximal caries at baseline,who used the MFP toothpaste with the xylitol-sorbitol mixture, showed　a lower (p less than 0.05) caries increment as compared with children　who used the MFP toothpaste with sorbitol alone.

Institutional address:

Medical and Dental Health Center　Halmstad　 Sweden.

Are sodium lauryl sulfate-containing toothpastes suitable vehicles for xylitol?

In: Eur J Oral Sci (1997 Apr) 105(2):178-82

The hypothesis to be tested in this study was that toothpastes containing sodium lauryl sulfate (SLS) is unsuitable vehicles for　xylitol. The bacteriostatic (and cariostatic) effect of xylitol is　assumed to be caused by intracellular accumulation of xylitol-5-P in　plaque bacteria. Experiments were designed to investigate whether presence of SLS would affect the uptake of xylitol by interacting　with the bacterial membranes and thus inhibit xylitol-5-P formation.It was shown in an in vitro study that even very low concentrations of the strong anionic detergent SLS inhibited uptake of xylitol and　xylitol-5-phosphate formation by dental plaque totally. The mild　nonionic detergent ethoxylated stearyl alcohol (30x EO) had no such　effect. In vivo experiments with toothpastes containing xylitol and　either the strong or the mild detergent, showed that xylitol in　toothpaste with SLS was not available for the plaque bacteria and　gave no adaptation to xylitol, whereas in the presence of 30x EO it　was available, and a xylitol adaptation was observed. Glucose metabolism, which was also studied for the plaque samples, was not significantly affected by presence of any of the 2 detergents,indicating that the amounts of xylitol in toothpastes were presumably too low to give clinical significant effects, even when mild detergents are used.

Institutional address:

Department of Oral Biology Faculty of Dentistry University of Oslo

Norway. assev@ulrik.uio.no

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